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CHIP was repeatedly found to be associated with a variety of adverse health outcomes, including hematological cancers, and also with a significantly elevated risk of atherosclerotic cardiovascular disorders which are a leading cause of death in the elderly (Evans et al., 2020)

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[DOI] [PubMed] [Google Scholar] 20.Marchitti S.A., Chen Y., Thompson D.C., Vasiliou V

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While certain functionalities can be achieved by directly modifying functional groups on the peptide sequence, this alteration may inevitably impact the primary role of the stapled peptide as a ligand in PPIs, mainly due to steric hindrance and other factors