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Assuming a 1:1:1 group allocation ratio, a sample size of 29 teeth per group was required to achieve 80% power to detect between-group differences

These solutions should always be stored at temperatures between 2-8C to ensure their effectiveness and prevent degradation over time

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Avoid chemical peels, microdermabrasion, laser treatments, or other aggressive exfoliants on areas where topical rapamycin is applied