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ELX- 02, a novel aminoglycoside analog, avoided serious adverse events in preclinical models [155] and Phase 1 clinical trials [156]

Furthermore, the study noted an apparent reduction in myeloperoxidase (MPO) activity, which is primarily found in neutrophils and is an enzyme involved in the model's response to inflammation

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Olink proteomic detection revealed that exosomes from HACE patients may be associated with altered expression of the STAMBP protein, which is related to neurodevelopment, and this alteration may contribute to cognitive dysfunction in mice

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