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The limit of 100 conformers was chosen as this is considered to be a standard number of conformers to be used in molecular modelling analyses and to balance computational time requirements whilst ensuring the production of an appropriate ensemble size [29]

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Undeclared pharmacologically active substances in illegal and falsified products can cause extreme harm to public health and pose a serious threat to human life

The success of the most advanced treatments is around 50%

Siugzdaite, R., Bathelt, J., Holmes, J., & Astle, D

One of the novel approaches is dual therapy with AMX and PPI