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The amino acid sequence is in the public domain and there is no composition-of-matter patent worth pursuing, so no commercial sponsor will fund the hundreds of millions a Phase IIIII development programme costs for a compound it cannot exclusively monetise

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A study found a novel HER2 aptamer (HB5) through SELEX and used it as a ligand to supply doxorubicin (Dox) to breast cancer cells in vitro