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The foldase activities of HSP70s require ATP, which binds in a Mg 2+ - and K + -dependent manner (Mas and Hiller, 2025)

A 2025 patent and literature review catalogued ongoing investigations into Src-caveolin-1 and focal adhesion kinase pathway involvement in tissue migration responses (PMID 40005999)

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As a result, only about 0.1% of a systemically administered monoclonal antibody reaches the brain parenchyma, explaining the high doses and dose-dependent side effects of antibody-based Alzheimers disease (AD) therapies

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