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Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies

Notably, NRF2-inducing compounds, such as tBHQ and sulforaphane, modify distinct KEAP1 residues from oxidation by ROS, thus allowing for an additive effect in the presence of oxidative stress (Suzuki et al., 2019

There is substantial heterogeneity across selenium intervention studies, and the differences in outcomes can largely be attributed to variations in population characteristics, baseline nutritional status, and study design

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