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Keller, F

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This naturally occurring substance aids in the transport of fatty acids into cells, where they are metabolized

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Most of the drug is processed by the liver and excreted through urine, with its pain-relieving effects lasting around 4 to 6 hours

We demonstrated that under AILI conditions, PARP1 catalyzed ribosylation of PXR at the residue E194, forming a PARP1PXRCYP3A4 regulatory axis that amplified oxidative stress and NAPQI accumulation through a positive feedback loop