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Acknowledgements The authors wish to thank Dr

Filtering water Activated charcoal is widely used to reduce heavy metal and fluoride content in water because it can trap carbon-based impurities, as well as chlorine

Therefore, inhibition of TXNIP should increase Trx1 activity

Ultimately, it is excreted through urine, with residual elimination via feces, partly influenced by gut microbiota (112)

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