Some of the drugs whose plasma concentrations are reduced and/or clearance rates are increased (thus resulting in a reduced effective concentration of the drug) by consumption of St Johns wort include: alprazolam (Xanax, Xanor, Alprax, Niravam: treatment of anxiety) amitriptyline (Elavil, Tryptizol, Laroxyl, Sarotex: a tricyclic antidepressant) atorvastatin (Lipitor: treatment for hypercholesterolemia) chlorzoxazone (Paraflex, Parafon Forte, Relaxazone, Remular-S: treatment of muscle spasms) ciclosporin (Cyclosporin: immunosuppressant used by organ transplant patients) debrisoquine (a guanidine derivative for treatment of hypertension) digoxin (Lanoxin, also known as digitalis: treatment of congestive heart failure, CHF) erythromycin (E-Mycin, Eryc, Ery-Tab, PCE, Pediazole, Ilosone: antibiotic used in upper and lower respiratory infections) fexofenadine (Allegra, Telfast, Fastofen, Tilfur: antihistamine for hay fever and allergy treatment) gliclazide (Glipizide: oral type 2 diabetes drug for lowering blood glucose) imatinib (Gleevec: chemotherapeutic for Philadelphia chromosome positive chronic myelogenous leukemia) indinavir (Crixivan: a protease inhibitor used as a component of highly active antiretroviral therapy, HAART) irinotecan (Camptosar: a topoisomerase I inhibitor used as chemotherapy drug for colo-rectal cancer) ivabradine (Procoralan: management of stable angina pectoris) mephenytoin (Mesantoin: an anticonvulsant) methadone (Symoron, Dolophine, Amidone, Methadose, Physeptone, Heptadon: synthetic opioid used to treat narcotic dependence and withdrawal) midazolam (Versed, Dormicum, Hypnovel: short acting injected sleep inducer for surgery, also produces amnesia) nifedipine (Adalat, Nifedical, Procardia: treatment of hypertension) omeprazole (Prilosec, Zegerid: proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease, PUD, and gastroesophageal reflux disorder, GERD) oral contraceptives quazepam (Doral, Dormalin: treatment of insomnia) simvastatin (Zocor: treatment for hypercholesterolemia) tacrolimus (FK-506 or Fujimycin: immunosuppressant used by organ transplant patients) verapamil (Isoptin, Verelan, Verelan PM, Calan, Bosoptin, Covera-HS: L-type calcium channel blocker for treatment of hypertension), voricoazole (VFEND: antifungal medication) warfarin (Coumadin, Jantoven, Marevan, Lawarin, Waran: anticoagulant)
Silverman, DC, DACBN, DCBCN, MS, CCN, CNS, CSCS, CIISN, CKTP, CES, HKC, FAKTR Protocols for Longevity: Optimizing Healthspan and Human performance **Sponsor: KBMO Diagnostics Presented by: Robert G
AntiCancer Agents in Medicinal Chemistry, 8(3), 313321
Whats Changing: The Reclassification to Category 1 The HHS announcement signals that approximately 14 of the 19 restricted peptides will be reclassified from Category 2 to Category 1
For IM injections, the site is cleaned, and the injection is administered into the muscle
Resources like SeekPeptides provide updated protocols, dosing charts , and community experiences that evolve as more real-world data becomes available
