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Gastrointestinal cell-line studies involving peptide-mediated regulation

Amalesh Nanda et al (75)

Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort

Furthermore, oxidative stress can enhance the expression of matrix metalloproteinases (MMPs), enzymes that degrade the extracellular matrix and facilitate tumor invasion and metastasis [116]

Both enzymes have moderate bioavailability in the GI tract and are not permeable through the bloodbrain barrier based on their ADME and drug-like properties

This multi-peptide configuration enables researchers to study pathway convergence and interaction effects within a single controlled experimental framework