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Prog Neuro-Psychopharmacol Biol Psychiatry 102:109958 Leclercq S et al (2021) Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms

In chronic fatigue syndrome, depression and GAD, the neurotoxicity theories conceptualize that the effects of neuro-oxidative stress toxicity (OSTOX) coupled with lowered antioxidant (ANTIOX) defenses cause increased neurotoxicity leading to somatic and affective symptoms [30, 31]

Environ Toxicol Pharmacol 2015;40:5770

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While the overall picture shows great promise, the wide variation in study designs and cell sources means it is not yet a universally standardized treatment