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Stability can be affected by formulation, storage, heat and oxidation

(ii) Cu 2+ induces the secretion of acidic SMase from leukocytes which in turn leads to accumulation of erythrocytic ceramide [131] and (iii) treatment of erythrocytes with extracellular SMase resulted in ceramide-associated alterations in membrane-cytoskeleton interactions and membrane organization [125]

Again, these findings are relevant solely to biochemical and molecular research and are not indicative of protective effects in living organisms