While direct contact between MenSCs and neurons inhibited neurite elongation, their secreted factorsincluding VEGF, HGF, and brain-derived neurotrophic factorpromoted axonal extension
The concentration of released Zn element was determined by an ICP-OES (Agilent)
Overexpression of FPN1 in neurons significantly reduces mitochondrial iron accumulation, alleviates lipid peroxidation, and improves pathological phenotypes in AD models (Bao et al., 2024
In conclusion, the impact of acute COVID-19 on the symptoms of Long COVID is partly mediated by OSTOX/ANTIOX, especially lowered Gpx and zinc, increased MPO and NO production and lipid peroxidation-associated aldehyde formation
Glutathione peroxidase (GPx) is an enzyme with peroxidase activity whose main biological role is to protect the cell from oxidative damage by reducing lipid hydroperoxides to their corresponding alcohols and reducing free hydrogen peroxide to water [21]
For example, the cytokine tumor necrosis factor-alpha (TNF-), produced during inflammation, can activate NF-B and other pro-survival pathways in cancer cells [112]
