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Inhibition of kynurenine 3-monooxygenase (KMO) significantly suppressed XA elevation and attenuated both oxygen-glucose deprivation (OGD)-induced cardiomyocyte injury and ligation-induced myocardial ischemia injury, suggesting XA's potential utility as a ferroptosis marker in CAD

261,262 Epidemiological and observational studies have consistently found that higher polyphenol consumption is linked to lower incidence of chronic degenerative disease

Normal aging leads to a progressive reduction of the glomerular filtration rate (GFR), but such changes do not occur in all individuals

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Morphologically, ferroptotic cells display shrunken mitochondria, increased membrane density, and reduced or absent mitochondrial cristae (Mou et al., 2019)