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The mechanism relies on glutathione as a cofactor, and disruptions in its availability can sensitize cells to ferroptosis

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BMJ 299(6709):12021203

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2,3 The hormonal imbalance, mainly of androgens, seems an important predisposing factor, as suggested by the characteristic localization of SD lesions (sebaceous gland-rich body areas target for androgens), age (adolescence) and sex (2:1 for men) prevalence of the manifestations