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The activity of jr PPO1-wt cleaved by trypsin was tested with the monophenolic substrate tyramine and the enzyme was unexpectedly inactive

PLoS ONE 7 , e52132 (2012)

The Philippines FDA has issued a formal warning against high-dose unsupervised cosmetic IV glutathione, and a 2025 case series in the International Journal of Dermatology documented liver function abnormalities in approximately half of high-dose IV-treated participants in unmonitored settings, which is precisely why the DermaVue protocol restricts dosing to the 400 to 1200 mg clinical range and enforces hepatic monitoring

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