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The GPX4 pathway is a central antioxidant axis that regulates ferroptosis, and its dysfunction is an important mechanism of cell death in ischemiareperfusion injury (275)

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At the same time, the activity of antioxidant enzymes (SOD, GPX, GR) in cardiomyocytes is weaker than that in other organs [17], further aggravating the susceptibility to this injury

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