10.1186/s13045-019-0720-y J Hematol Oncol
Popular Brands Hospira (Pfizer) Cyanocobalamin Injection American Regent Cyanocobalamin Fresenius Kabi Cyanocobalamin Sandoz Cyanocobalamin Teva Cyanocobalamin Strengths 1000 mcg/mL (standard adult & clinical dose) 500 mcg/mL (pediatric or dose-adjusted therapy) 2000 mcg/mL (high-strength for severe deficiency) Typical regimen: 1000 mcg IM weekly, then monthly maintenance (per healthcare providers direction)
Heres my game plan: Test for intrinsic factor antibodies if my doctor offers this Try high-dose sublingual B12 (5000mcg daily) for 8 weeks as a test If my B12 stays below 400 pg/mL, go straight to injections Calculate the cost difference to justify the investment The 10% Rule If youre absorbing less than 10% of your oral B12 (you can estimate this by comparing your supplement dose to your blood response), weekly shots often cost less than daily high-dose pills
Hansen, Jakob Lerche
This transformation requires coordinated changes across medical education, clinical practice, healthcare systems, and research priorities
Several factors that increase the induction of CYP2E1, including smoking, obesity, vinyl chloride, and exposure to trichloroethylene are associated with increased incidence of autism
