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Accordingly, our models predicted a strong induction of several metabolic pathways in non-infected cells of COVID-19 patients based on an increased number of reactions active in the respective context-specific metabolic models, which was even more pronounced in patients with severe disease (Fig

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N-Glutaryl-L-alanine (GA) is one of the potent inhibitor for GGCT activity, but GA has little membrane-permeability

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In some embodiments, the neutral polymer forms a polymer matrix that encapsulates the therapeutic agent and provides for the sustained release of the therapeutic agent