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Accordingly, high mTORC1 activity in cancer cells promotes aerobic glycolysis and drives glucose addiction 162,163 (Fig

Recent studies have shown that preconditioning can also activate changes at the gene level, which involves activation of molecules, such as transcription factors, transducers, sensors, and effectors, as well as numerous post-translational modifications

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[DOI] [PubMed] [Google Scholar] Dichtl W, Dulak J, Frick M, Alber HF, Schwarzacher SP, Ares MPS, Nilsson J, Pachinger O, Weidinger F, 2003

Dysregulation of the immune system impairs the function and number of Treg cells, which are essential for maintaining self-tolerance, while increasing the differentiation of proinflammatory Th1 and Th17 cells [34,35,36]