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This finding indicates that both drugs could permeate the BBB over time and reach the tissue compartment

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Cholesterol metabolism is deregulated in tumors, which exhibit a paradoxical stimulation in de novo cholesterol synthesis despite hypoxia-mediated downregulation of HMG-CoA reductase by hypoxia ( Figure 4 )

The interplay between hyperglycemia and oxidative stress contributes to the pathogenesis of diabetic complications, including neuropathy, nephropathy, retinopathy, and cardiovascular diseases [172]

Declarations Conflict of interest The authors declare that they have no conflict of interest

The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy