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While the preclinical safety profile appears favorable (few adverse effects reported in animal studies), this does not guarantee the same in humans, especially with prolonged use

Neuroprotective effects of GHK-Cu on amyloid-beta and tau pathology in cellular models of Alzheimer's disease

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The authors conclude that the findings indicate that the Rhodiola rosea extracts and salidroside commonly induce hormetic dose responses within a broad range of biological models and cell types and across a wide range of endpoints, with particular emphasis on longevity and neuroprotective endpoints [269]

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