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Combining the RIPK1 inhibitor with the BCL-2 inhibitor venetoclax promotes apoptosis in AML cells and overcomes resistance to single-drug treatment (139)
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Functional pathway readouts as practical proxies Assays that quantify the activity of zinc-sensitive organelle pathways, such as secretory pathway processing, glycosylation capacity, UPR activation or lysosomal proteolysis, may provide clinically actionable proxies for luminal zinc availability and transporter performance
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