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However, regarding the nasal spray, microparticles are not expected to penetrate the mucin barrier that protects the respiratory epithelial cells (3941), and so this now motivates a deeper physicochemical evaluation of niclosamide and especially how to increase its concentration in solution using simple buffers to access the epithelial cells

There was no epidermal layer observed in both groups B and C, and granulation tissue was also generated and inflammatory cells were observed in both groups

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A representative experiment of the three is shown