Cells were treated with 0 or 10 mmol/L of PhS for 24 hours and then treated with hydrogen peroxide (0, 10, 20 mol/L) for 5 hours in the absence or presence of reduced glutathione (0, 0.05, 0.1, 0.2, 0.5 mmol/L)
demonstrated dose-dependent proliferation effects on cultured human dermal papilla cells exposed to GHK-Cu at physiologically relevant concentrations.3 Subsequent work has confirmed that this effect translates into upregulation of genes associated with anagen-phase activity including VEGF, FGF-2, and IGF-1, the three growth factors most directly implicated in hair-cycle regulation
We believe this can be more valuable than checklist-based approaches such as Cochrane GRADE, which can be easily influenced by potential bias, may ignore or underemphasize serious issues not captured in the checklists, and may overemphasize issues unlikely to alter outcomes in specific cases (for example certain specifics of randomization with a very large effect size and well-matched baseline characteristics)
Michalzik enthlt reines nicht oxidiertes Glutathion
Ridet JL, Bensadoun JC, Deglon N, Aebischer P, Zurn AD
For both age groups, we identified a positive correlation between frontal and sensorimotor GSH levels, as well as higher GSH levels for the sensorimotor compared to the frontal voxel
