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B12 deficiency is one of the most common and most frequently overlooked nutritional deficiencies, affecting those on plant-based diets, adults over 50, individuals on certain medications, and anyone with reduced gastrointestinal absorption

"Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials"

US Department of Agriculture

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Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)