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doi:10.1038/s42255-020-0181-1

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Targeting the IGF-1R signaling pathway is considered a potential breakthrough in anticancer therapy and a number of small molecule inhibitors and monoclonal antibodies targeting IGF-1R, such as BIIB-022, BMS-754807 and Teprotumumab, have been developed and evaluated in clinical trials (113115)

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Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation