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When stress becomes chronic, the hypothalamicpituitaryadrenal (HPA) axis becomes dysregulated

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These compounds differ in how they work, what they target, how long they stay active in the body, and what evidence exists to support their use

Other intranasal preparations being explored in Parkinsons include dopamine, one using gene therapy, a vitamin E loaded naringenin, stem cells, glial cell-derived neurotrophic factor (GDNF), carnosine, BDNF, intranasal insulin, rotigotine, and estradiol

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