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They also confirmed that concurrent treatment with JHU083 and anti-PD-1 checkpoint inhibitor improved the antitumor effects compared with anti-PD-1 treatment alone, suggesting the presence of metabolic plasticity between cancer cells and effector T cells, which could be exploited as a metabolic checkpoint for cancer immunotherapy 200

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Gourdon P, Liu X-Y, Skjrringe T, Morth JP, Mller LB, Pedersen BP, Nissen P

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No GHK-Cu drug products have received FDA approval