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Common reasons for an imbalanced ratio between phosphatidylcholine and cholesterol include: Fasting Overeating High-fat diet Ketogenic diet Vegan diets Protein deficiency Low dietary choline intake Low dietary glycine intake Methylation disregulation Dirty MTHFR Dirty PEMT Dehydration Low stomach acid Ongoing intake of proton pump inhibitors (PPIs) Bacterial overgrowth of specific bacteria such as certain Clostridia species What Happens When You Dont Have Healthy Bile Composition or Bile Flow

For gut-specific use, oral may be adequate

doi: 10.1186/s12906-016-1540-z 8 Alves-BezerraM.CohenD

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Joe Moore: Yeah, and Stan and Lenny had conversations about this same thing

One of the critical components of this excretion system is the liver