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Cycling the protocol, taking periodic breaks of two to four weeks before resuming, may help reset receptor sensitivity

This is consistent with the known anti-inflammatory mechanisms of Spirulina, which include suppression of pro-inflammatory cytokines(IL-6,TNF-) and inhibition of NF- NF-B [63, 107]

In line with the observed transcriptional changes of writers and erasers of DNA methylation, 71% of the DMRs corresponded to gain of methylation (46,984 hypermethylated regions vs 19,194 hypomethylated regions)

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Jurcu MC, Andronie-Cioara FL, Jurcu A et al (2022) The link between oxidative stress, mitochondrial dysfunction and neuroinflammation in the pathophysiology of Alzheimers disease: therapeutic implications and future perspectives