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Lancet , 2 (8405), 719721

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Mitochondrial dysfunction leading to overproduction of ROS, which triggers oxidative stress and promotes upregulation of NFAT [21, 22]

1 Schadendorf D, Wolchok JD, Hodi FS, et al

Structural Metal Sites A structural metal ion stabilizes the protein fold and might be considered the inorganic analog of a long-lived disulfide bond that is found in proteins that reside in, or transit the endoplasmic reticulum in eukaryotic cells, and fulfills its function in the more oxidizing environment of the extracellular space

In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy