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Moreover, free phenolic extract from rape BP possesses higher capabilities to defend body cells from aberrant melanogenesis than bound phenolic extract via the suppression of microphthalmia-associated transcription factor (MITF) and downregulation of cyclic adenosine monophosphate (cyclic adenosine monophosphate) while preventing the anti-tyrosinase and antioxidant pathways in vitro ( Givotia rottleriformis diminish the growth of skin cancer cells (human epidermoid carcinoma) (149) and restrain hepatitis C virus (HCV) which causes hepatocellular carcinoma and liver cirrhosis (150)