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For the treatment of gastrointestinal issues, it is recommended to take this medicine on an empty stomach or before having meals, because it raises the absorption and efficacy of the medicine

PMID 12086562

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Quay TAW, Schroder TH, Jeruszka-Bielak M, Li W, Devlin AM, Barr SI, et al

A- Yes, it is often used for diabetic neuropathy and is regarded as safe