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These cytokines are responsible for the imbalance between lipid peroxidation and antioxidant defense mechanisms and, in turn, lead to endothelial activation and free-radical-mediated cell damage [81]

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Neurotherapeutics 19 (6), 19661975

It concentrates in tissues under high oxidative stress, including the eyes, liver, and kidneys

Although comparative studies have showed that Hunner lesions patients are older, 86, 87, 101-103 have greater urinary frequency and nocturia, 86, 87, 102, 103 higher ICSI scores, 86, 87, 103 and lower bladder capacity 101, 103 compared to those without Hunner lesion, cystoscopy remains the only reliable way to diagnose the presence or absence of Hunner lesions given the overlaps in clinical symptomatology

In patients with MS, ALA has some positive outcomes, especially in the enhancement of walking and balance disabilities, while decreasing the levels of some proinflammatory factors related to MS progression