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Due to the role played by GSH in regulating redox balance, some molecules involved in GSH metabolism, such as glutathione peroxidase 4 (GPX4), GCLC and the cystine transporter solute carrier family 7 member 11 (SLC7A11), have been reported to inhibit the ferroptosis of cancer cells 38,39,40,41,42,43,44

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4b) Whether these accumulated ROS can alter signal transduction has not been examined in the context of G6PD-d

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Most protocols recommend a 2 to 4 week break between cycles