In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself
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In contrast, 14 states Alabama, Arizona, Delaware, Florida, Georgia, Kentucky, Louisiana, Mississippi, Montana, Nevada, South Carolina, Tennessee, Utah and Wyoming will need at least three times the number of practicing geriatricians in 2050 as there were in 2021 to care for those projected to have Alzheimer's dementia
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Alzheimers Dement 2022;18:754767
