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Studies have found that several factors, such as treatment chronicity, financial concerns, and adhesion hurdles related to the change from the pediatric to the adult healthcare system, affect SCD patients' poor adherence to HU [5, 111,112,113]

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When the right peptide binds with the right receptor, it triggers a specific function, such as releasing hormones, burning fat, or increasing metabolism

However, there can also be an intact BBB which can limit effective treatment by hindering homogeneous uptake of administered therapeutic agents (Figure 2B summarizes the main processes driving BBB disruption, the key factors involved and the role of BBB imaging in neuro-oncology

Link Sikiric P, et al