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*Correspondence: Ming Li, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Topaz trained-based autopicking in cryoSPARC (v4.5.0) was implemented to select particle images, resulting in 3,216,504, 3,182,579, and 6,617,058 particles respectively from each dataset 61,63