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STAT3-RXR-Nrf2 activates systemic redox and energy homeostasis upon steep decline in pO2 gradient

Systemic immune suppression by Candida mycotoxins reduces local immune surveillance at the nail bed, permitting fungal colonisation that would ordinarily be cleared by resident immune cells

These are consistent with the mechanism of action slowing gastric emptying affects digestion, and central appetite suppression can cause nausea, particularly during the early stages of treatment and dose escalation

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