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Oxidation specific epitopes (OSE) present on the surface of oxLDL are major targets for natural IgM (IgM OSE )

10.1016/j.phymed.2022.154583 67 MasscheleinE.Van ThienenR.DHulstG.HespelP.ThomisM.DeldicqueL

MicroRNAs, on the other hand, pose pharmacokinetic problems

A dense extracellular matrix (ECM), rich in collagen and hyaluronic acid, forms a physical barrier that restricts drug penetration and distribution

The donor electronegativity of these three molecules is very similar, so a comparable charge transfer process can be expected to occur from these anions to the copper complexes