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However, large-scale randomized controlled trials in humans are absent, limiting evidence for clinical safety and efficacy claims

PCAC consultation planned by end of February 2027)

Pernicious anaemia is a lifelong condition, and patients will require B12 injections indefinitely

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Gastrointestinal disorders were not dependent on cagrilintide dose, with 1238 events occurring in 7 (58%) of 12 participants to 11 (92%) of 12 participants given cagrilintide 0.164.5 mg in combination with semaglutide 2.4 mg, compared with 50 events occurring in 19 (79%) of 24 pooled participants given placebo in combination with semaglutide 2.4 mg

Research has explored its receptor selectivity compared with earlier growth hormone secretagogues, making it a valuable model for studying GH-related signaling pathways