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Alcohol: Alcohol leads to increased oxidative stress and inflammation

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ROS-induced promotion of viral pathogenesis Moderate ROS levels are necessary for numerous cellular functions, including gene expression 58

Horm Behav 165:105616

ROS will also induce endoplasmic reticulum stress and more mitochondria dysfunction, and eventually, more ROS will be formed

Figure 1 3.3 Effects of glutathione feeding on the activities of immunity-related enzymes in bullfrog serum As shown in Figure 2 , SOD activity was elevated and AKP activity was decreased in the serum of bullfrogs in the glutathione group compared to the FI group