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Vijay-KumarMAitkenJDCarvalhoFACullenderTCMwangiSSrinivasanSet alMetabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5

Over time, stress, poor nutrition, and environmental toxins can deplete our natural stores of this antioxidant

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10.1038/nature10263 120 ShanJ.SchwartzR

While short-term use may cause only transient effects, prolonged supraphysiological IGF-1 receptor activation could potentially cause unwanted tissue growth including cardiac hypertrophy, which at extreme levels could impair cardiac function, and growth of other organs