is glutathione toxic Acetaminophen metabolism and NAPQI-mediated mitochondrial effects Reason for not using Glutathione

doi:10.1038/d41586-019-02667-5

11.2 Summary of RCTs In a single double-blind crossover RCT by Carlsten et al

10.1097/ALN.0b013e3182829b7b 215 ZhangZ.ZhaoS.WuH.QinW.ZhangT.WangY.et al (2022b)

Among the ten in vivo studies, although various dosages were tested, neither a clear dose-response relationship nor long-term toxicity assessments (e.g., liver and kidney function indicators) were reported (Wang et al., 2023c

This ensures reliable and reproducible results for laboratory studies

These differences in GST type and multiplicity, as well as residue changes that impact the secondary and tertiary structure of the cat and dog GST proteins, affect substrate selectivity and catalytic efficiency