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Targeted delivery of p-coumaric acid encapsulated mannosylated liposomes to the synovial macrophages inhibits osteoclast formation and bone resorption in the rheumatoid arthritis animal model

The transcription factor involved in response to amino acid starvation is activating transcription factor 4 (ATF4), which binds to the CSE promoter in addition to promoters of other amino acid biosynthetic and transport genes (Harding et al ., 2003)

in contrast, overexpressing LRRFIP1 had the opposite effects

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin