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This can supplement diet, exercise, and other nonpharmacologic interventions

vitamin C drives hydroxylation

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Rong, P., et al

These links reflect shared immunogenetic factors, including IL-18, IFN-, CTLA-4, HLA-DQ8, HLA-DQ2, HLA-B8, and HLA-DR3, many of which are integral to antigen presentation within the major histocompatibility complex (MHC)