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Importantly, a mutation in PNPLA3 (rs738409), I148M, is the single greatest genetic risk factor for the development of FLD (64-67), however its precise function in neutral lipid metabolism is controversial (68, 69)

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Although differences have been observed between these models, a great deal of insight has been gained regarding the relative contribution of HSL to adipocyte TAG hydrolysis

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doi:10.1080/10408398.2015.1117413

With continued use, GnRH agonists lead to lower levels of FSH and LH, with reduced sex hormone production