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Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats

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Systemic effects remain less certain because peptides are generally broken down during digestion, which reduces the amount that reaches circulation in active form

See Sikiric et al., Curr Pharm Des, 2018 (PMID:30246642) for an overview of the reported mechanisms, and Chang et al., J Appl Physiol, 2011 (PMID:21030673) for a representative tendon-fibroblast study